Jae-woo Park*, Woo-gyun Choi*, Phil-jun Lee, Su-wol Chung, Byung-sam Kim, Hun-taeg Chung, Sungchan Cho, Jong-heon Kim, Byoung-heon Kang, Hyoungsu Kim, Hong-pyo Kim, Sung-hoon Back (2017) 

The novel resveratrol derivative 3,5-diethoxy-3',4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro. (Cover Story).

Acta Pharmacolica Sinica 38(11):1486-1500. *These authors contributed equally to this work.

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Woo-Gyun Choi*, Jaeseok Han*, Ji-Hyeon Kim*, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo*, Randal J. Kaufman* and Sung Hoon Back* (2017)

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Nutrition & Metababolism (London). 14(48):1-21. *These authors contributed equally to this work.

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Jihyeon Yang, Chu-Sook Kim, Thai Hien Tu, Min-Seon Kim, Tsuyoshi Goto, Teruo Kawada, Myung-Sook Choi, Taesun Park, Mi-Kyung Sung, Jong Won Yun, Suck-Young Choe, Jee Hye Lee, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Hun Taeg Chung and Rina Yu (2017)

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction.

Nutrients. 9(7):1-14.

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Su Hee Kim, Ha Eun Song, Su Jung Kim, Dong Cheol Woo, Suhwan Chang, Woo Gyun Choi, Mi Jeong Kim, Sung Hoon Back, and Hyun Ju Yoo (2017)

Quantitative structural characterization of phosphatidylinositol phosphates from biological samples.

Journal of Lipid Research 58(2): 469-78.

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Jaeseok Han, Benbo Song, Jiun Kim, Vamsi K. Kodali, Anita Pottekat, Miao Wang, Justin Hassler, Shiyu Wang, Subramaniam Pennathur, Sung Hoon Back, Michael G. Katze, Randal J. Kaufman1 (2015)

Antioxidants complement the requirement for protein chaperone function to maintain beta cell function and glucose homeostasis.

Diabetes 64(8):2892-904.

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Seong Hun Kim , Kook Hwan Kim, Hyoung-Kyu Kim, Mi-Jeong Kim, Sung Hoon Back, Morichika Konishi , Nobuyuki Itoh and Myung-Shik Lee (2015)

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress.

Diabetologia 58(4):809-18.

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Hyunju Kang, Jaehyung Song, Kwangman Choi, Hyeongki Kim, Miri Choi, So-Young Lee, Chonsaeng Kim, Sang Jun Lee, Moon Jung Song, Hyojeung Kang, Sung Hoon Back, Sang-Bae Han and Sungchan Cho (2014)

Efficient lytic induction of Kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines. Oncotarget 5(18):8515-27.

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Kwangman Choi, Hyeongki Kim, Hyunju Kang, So-Young Lee, Sang Jun Lee, Sung Hoon Back, Seo Hyun Lee, M. Sun Kim, Jeong Eun Lee, Ju Young Park, Jiye Kim, Sunhong Kim, Jae-Hyung Song, Yura Choi, Suui Lee, Hyun-Jun Lee, Jong Heon Kim and Sungchan Cho (2014)

Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.

FEBS Journal 281(13):3048-60.

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Su Jung Kim, Sung Hoon Back, Jung Min Koh and Hyun Ju Yoo (2014)

Quantitative determination of major platelet activating factors from human plasma.

Analytical and Bioanalytical Chemistry. 406(13):3111-8.

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Sena Kim, Yeonsoo Joe, Sun Oh Jeong, Min Zheng, Sung Hoon Back, Sang Won Park, Stefan W Ryter and Hun Taeg Chung (2014)

Endoplasmic reticulum stress is sufficient for the induction of IL-1b production via activation of the NF-kB and inflammasome pathways.

Innate Immunity 20(8):799-815

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Jagannath Misra, Dipanjan Chanda, Don-Kyu Kim, Seung-Rye Cho, Seung-Hoi Koo, Chul-Ho Lee, Sung Hoon Back, Hueng-Sik Choi (2014)

Orphan nuclear receptor Errg induces C-reactive protein gene expression through induction of ER-bound bzip transmembrane transcription factor CREBH.

PLoS One. 9(1):e86342 1-9.

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Jagannath Misra, Don-Kyu Kim, Woogyun Choi, Seung-Hoi Koo, Chul-Ho Lee, Sung Hoon Back, Randal J. Kaufman and Hueng-Sik Choi (2013)

Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response.

Nucleic Acids Research 41(14):6960-74.

 

Jaeseok Han*, Sung Hoon Back*, Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve, Jixiu Shan, Celvie L. Yuan, Dawid Krokowski, Shiyu Wang , Maria Hatzoglou, Michael S. Kilberg, Maureen A. Sartor, Randal J. Kaufman (2013)

Endoplasmic reticulum (ER) stress-induced transcriptional regulation increases protein synthesis leading to cell death.

Nature Cell Biology 15:481–490.  *These authors contributed equally to this work.

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Hyunsun Jo, Sung Sik Choe, Kyung Cheul Shin, Hagoon Jang, Jae Ho Lee, Je Kyung Seong, Sung Hoon Back and Jae Bum Kim (2013)

ER stress induces hepatic steatosis via increased expression of the hepatic VLDL receptor. Hepatology 57(4):1366-77.

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Kook Hwan Kim, Yeon Taek Jeong, Hyunhee Oh, Seong Hun Kim, Jae Min Cho, Yo-Na Kim, Su Sung Kim, Do Hoon Kim, Kyu Yeon Hur, Hyoung Kyu Kim, TaeHee Ko, Jin Han, Hong Lim Kim, Jin Kim, Sung Hoon Back, Masaaki Komatsu, Hsiuchen Chen, David C Chan, Morichika Konishi, Nobuyuki Itoh, Cheol Soo Choi and Myung-Shik Lee (2013)

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine.

Natature Medicine 19(1):83-92.

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Sung Hoon Back and Randal J. Kaufman (2012)

Endoplasmic Reticulum Stress and Type 2 Diabetes.

Annual Review Biochemistry 81:767-793.

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Min Zheng, Seul-Ki Kim, Yeonsoo Joe, Sung Hoon Back, Hong R. Cho, Hong Pyo Kim, Louis J. Ingnarro, and Hun-Taeg Chung (2012)

Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity.

FASEB Journal 26(6):2558-68.

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Sook-Kyoung Heo, Seong-A Ju, Gyu Yeol Kim, Sang-Min Park, Sung Hoon Back, Neung-Hwa Park, Young Joo Min, Won G. An, Thu-Ha Thi Nguyen, Sun-Min Kim and Byung-Sam Kim (2012)

The presence of high level soluble herpes virus entry mediator in sera of gastric cancer patients.

Experimental Molecular Medicine 44(2):149-58.

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Jagannath Misra, Dipanjan Chanda, Don-kyu Kim , Tiangang Li, Seung-Hoi Koo, Sung Hoon Back, John Y. L. Chiang and Hueng-Sik Choi (2011)

Curcumin differentially regulates ER-stress through transcriptional corepressor SMILE mediated inhibition of CREBH transactivation.

Journal of Biological Chemistry 286(49):41972-84.

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Sung Hoon Back, Sang-Wook Kang, Jaeseok Han, and Hun-Taeg Chung (2011)

Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes.

Experimental Diabetes Research 2012;2012:618396.

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Kezhong Zhang, Shiyu Wang, Jyoti Malhotra, Justin R Hassler, Sung Hoon Back, Guohui Wang, Lin Chang, Wenbo Xu, Hongzhi Miao, Roberta Leonardi, Y Eugene Chen, Suzanne Jackowski and Randal J. Kaufman (2011)

The unfolded protein response transducer IRE1a prevents ER stress-induced hepatic steatosis.

The EMBO journal. 30(7):1357-75.

 

Hong Pyo Kim, Hyun-Ock Pae, Sung Hoon Back, Su Wol Chung, Jae Moon Woo, Yong Son, Hun-Taeg Chung (2011)

Heme oxygenase-1 comes back to endoplasmic reticulum.

Biochemical and Biophysical Research Communications 404(1):1-5.

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Randal J. Kaufman, Sung Hoon Back, Benbo Song, JaeSeok Han, Justin R. Hassler (2010)

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells.

Diabetes Obesis Metab. Supplement 2:99-107.

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Sung Hoon Back*, Donalyn Scheuner*, JaeSeok Han, Benbo Song, Mark Ribick, Junying Wang, Subramaniam Pennathur, and Randal J. Kaufman (2009)

Translational control through eIF2a phosphorylation prevents oxidative stress and maintains the differentiated state in b cells (Cover Story).

Cell Metabolism 10: 13-26. *These authors contributed equally to this work.

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Hemamalini Bommiasamy*, Sung Hoon Back*, Paolo Fagone, Kyungho Lee, Sasha Meshinchi, Elizabeth Vink, Rungtawan Sriburi, Matthew Frank, Suzanne Jackowski, Randal J. Kaufman, and Joseph W. Brewer (2009)

ATF6a Induces XBP-1-Independent Expansion of the Endoplasmic Reticulum.

Journal of Cell Science 122(10): 1626-1636. *These authors contributed equally to this work.

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Sung Hoon Back, Justin R. Hassler, and Randal J. Kaufman (2009)

The Unfolded Protein Response in Mammalian Cells.

Bentham Science eBooks (Protein Misfolding Disorders:A trip to the ER, eISBN: 978-1-60805-013-0, 2009).

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D. Thomas Rutkowski, Jun Wu, Sung Hoon Back, Michael U. Callaghan, Sean P. Ferris, Jahangir Iqbal, Robert Clark, Hongzhi Miao, Justin R. Hassler, Jamie Fornek, Michael G. Katze, M. Mahmood Hussain, Benbo Song, Jayanth Swathirajan, Junying Wang, Grace D.-Y. Yau, and Randal J. Kaufman (2008)

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

Devemental Cell 15(6):829-840.

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Jiahai Zhou, Chuan Yin Liu, Sung Hoon Back, Robert L. Clark, Daniel Peisach, Zhaohui Xu , and Randal J. Kaufman (2006)

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.

Proceedings of the National Academy of Sciences of the United States of America 103(39):14343-14348.

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Kezhong Zhang, Xiaohua Shen, Jun Wu, Kenjiro Sakaki, Thomas Saunders, D. Thomas Rutkowski, Sung Hoon Back, and Randal J. Kaufman (2006)

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.

Cell 124(3):587-599.

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Sung Hoon Back, Kyungho Lee, Elizabeth Vink, and Randal J. Kaufman. (2006)

IRE1-mediated XBP mRNA splicing in the absence of nuclear processing and ER stress.

Journal of Biological Chemistry 81(27):18691-706.

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Sung Hoon Back, Martin Schröder, Kyungho Lee, Kezhong Zhang, and Randal J. Kaufman. (2005)

ER Stress signaling by Regulated Splicing: IRE1/HAC1/XBP1.

Methods 35(4):395-416.

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Sungchan Cho, Jong Heon Kim, Sung Hoon Back, and Sung Key Jang. (2005)

Polypyrimidine Tract-Binding Protein Enhances the Internal Ribosomal Entry Site-Dependent Translation of p27Kip1 mRNA and Modulates Transition from G1 to S Phase.

Molecular and Cellular Biology 25(4):1283–1297.

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Woo Jae Kim*, Sung Hoon Back*, Vit Kim, Incheol Ryu and Sung Key Jang. (2005)

Sequestration of TRAF2 into stress granules interrupts TNF signaling during heat shock.

Molecular and Cellular Biology 25(6):2450-2462. *These authors contributed equally to this work.

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Sung Hoon Back, Sejeong Shin, and Sung Key Jang. (2002)

Polypyrimidine Tract-binding proteins are cleaved by caspase-3 during apoptosis.

Journal of Biological Chemistry 277(30):27200-27209.

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Sung Hoon Back, Yoon Ki Kim, Woo Jae Kim, Sungchan Cho, Hoe Rang Oh, Jung-Eun Kim, and Sung Key Jang. (2002)

Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3Cpro.

Journal of Virology 76(5): 2529-2542.

 

Yoon Ki Kim, Sung Hoon Back, Jungmin Rho, Song Hee Lee, and Sung Key Jang. (2001)

La autoantigen enhances translation of BiP mRNA.

Nucleic Acids Research 29(24):5009-5016.

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Sung Yun Kim, Kye Won Park, Yong Jae Lee, Sung Hoon Back, Jae Hwan Goo, Ohkmae K. Park, Sung Key Jang, and Woo Jin Park. (2000)

In Vivo Determination of Substrate Specificity of Hepatitis C Virus NS3 Protease: Genetic Assay for Site-Specific Proteolysis.

Analytical Biochemistry 284(1):42-48.

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Sung Hoon. Back, Jung-Eun Kim, Jungmin Rho, Bumsuk Hahm, Tae-Gyu Lee, Eunice E. Kim, Joong-Myung Cho, and Sung K. Jang. (2000)

Expression and purification of an active, full-length hepatitis C viral NS4A.

Protein Expression and Purification 20(2):196–206.

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Jung-Eun Kim, Woo Keun Song, Kyung Min Chung, Sung Hoon Back, and Sung Key Jang. (1999)

Subcellular localization of hepatitis C viral proteins in mammalian cells.

Archives of Virology 144(2):329–343.

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Hyun-Soo Cho, Nam-Chul Ha, Lin-Woo Kang, Kyung Min Chung, Sung Hoon Back, Sung Key Jang, and Byung-Ha Oh. (1998)

Crystal Structure of RNA Helicase from Genotype 1b Hepatitis C Virus.

Journal of Biological Chemistry 273(24):15045–15052.

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Lin-Woo Kang, Hyun-Soo Cho, Sun-Shin Cha, Kyung Min Chung, Sung Hoon Back, Sung Key Jang, Byung-Ha Oh. (1998)

Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein.

Acta Crystallographica D54 (part 1):121-123.

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Bumsuk Hahm, Sung Hoon Back, Tae Gyu Lee, Eckard Wimmer, and Sung Key Jang. (1996)

Generation of a novel poliovirus with a requirement of hepatitis C Virus NS3 protease activity.

Virology 226(2):318-326.

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Bumsuk Hahm, Dae Sung Han, Sung Hoon Back, Ok-Kyu Song, Myung-Jae Cho, Chul-Joong Kim, Kunitada Shimotohno, and Sung Key Jang. (1995)

NS3-4A of hepatitis C virus is a chymotrypsin-like protease.

Journal of Virology 69(4):2534-2539.